{"id":4145,"date":"2021-03-16T09:00:36","date_gmt":"2021-03-16T09:00:36","guid":{"rendered":"https:\/\/endoscopiaterapeutica.net\/pt\/uncategorized\/caso-clinico-carcinoma-neuroendocrino-de-esofago\/"},"modified":"2022-07-11T07:48:17","modified_gmt":"2022-07-11T07:48:17","slug":"caso-clinico-carcinoma-neuroendocrino-de-esofago","status":"publish","type":"post","link":"https:\/\/endoscopiaterapeutica.net\/pt\/casosclinicos\/caso-clinico-carcinoma-neuroendocrino-de-esofago\/","title":{"rendered":"Caso cl\u00ednico: carcinoma neuroend\u00f3crino de es\u00f4fago"},"content":{"rendered":"

Relato de caso<\/b><\/h2>\n

Homem, 45 anos, com antecedente de etilismo e tabagismo, vinha em acompanhamento com a oncologia ap\u00f3s <\/span>mandibulectomia com esvaziamento cervical por CEC<\/a> (pT4a N2c),<\/span> seguida de quimioterapia e radioterapia adjuvantes. No acompanhamento, cerca de 9 meses ap\u00f3s cirurgia, <\/span>PET-CT revelou capta\u00e7\u00e3o em regi\u00e3o esof\u00e1gica m\u00e9dia com linfonodo adjacente, al\u00e9m de m\u00faltiplos n\u00f3dulos hep\u00e1ticos (imagens abaixo).<\/span><\/p>\n

Solicitada endoscopia, fotos abaixo:<\/span><\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"Carcinoma<\/a>\"Carcinoma<\/a><\/p>\n

\"Carcinoma<\/a><\/p>\n

\"Carcinoma<\/a><\/p>\n

\"Carcinoma\"\"<\/a>\"Carcinoma<\/a>\"Carcinoma<\/a><\/p>\n

A <\/span>endoscopia<\/span><\/a> revelou les\u00e3o plano-elevada em es\u00f4fago m\u00e9dio medindo cerca de 3 cm, com acometimento de 50% da circunfer\u00eancia do \u00f3rg\u00e3o, com intensa irregularidade da vasculariza\u00e7\u00e3o e da superf\u00edcie mucosa \u00e0 magnifica\u00e7\u00e3o com NBI e sendo uma les\u00e3o iodo-negativa \u00e0 cromoscopia com lugol (2%). Bi\u00f3psias revelaram carcinoma neuroend\u00f3crino predominantemente de pequenas c\u00e9lulas, com Ki-67 de 50%. Ademais, bi\u00f3psia de n\u00f3dulo hep\u00e1tico tamb\u00e9m exibiu carcinoma neuroend\u00f3crino de pequenas c\u00e9lulas com Ki-67 de 70%. Logo, comprovada a exist\u00eancia de 2\u00ba tumor prim\u00e1rio, o carcinoma neuroend\u00f3crino de pequenas c\u00e9lulas no es\u00f4fago de alto grau metast\u00e1tico para o f\u00edgado. Paciente foi encaminhado para acompanhamento com oncologia. <\/span><\/p>\n

Discuss\u00e3o\/Conclus\u00f5es<\/h3>\n

Tumores neuroend\u00f3crinos<\/span><\/a> (TNE) s\u00e3o neoplasias heterog\u00eaneas por apresentarem caracter\u00edsticas histol\u00f3gicas diversificadas e apresenta\u00e7\u00f5es cl\u00ednicas variadas. Apesar da relativa raridade, houve um aumento da incid\u00eancia nos \u00faltimos anos, justificada, principalmente, pela melhora dos m\u00e9todos diagn\u00f3sticos. A maioria dos carcinomas neuroend\u00f3crinos de pequenas c\u00e9lulas s\u00e3o advindas do pulm\u00e3o, sendo as apresenta\u00e7\u00f5es extrapulmonares mais raras.<\/span><\/p>\n

O carcinoma neuroend\u00f3crino de pequenas c\u00e9lulas do es\u00f4fago<\/a> \u00e9 um tipo raro de neoplasia, caracterizado por apresentar comportamento agressivo e por mau progn\u00f3stico, evoluindo com met\u00e1stases e, por conseguinte, com sobrevida estimada em meses. Por serem extremamente incomuns, h\u00e1 poucas publica\u00e7\u00f5es sobre o tema.<\/span><\/p>\n

Como citar este artigo<\/h3>\n

Ruiz RF. Caso cl\u00ednico: Carcinoma Neuroend\u00f3crino de Es\u00f4fago. Endoscopia Terap\u00eautica; 2021. Dispon\u00edvel em: https:\/\/endoscopiaterapeutica.net\/pt\/casosclinicos\/caso-clinico-carcinoma-neuroendocrino-de-esofago<\/span><\/p>\n

Refer\u00eancias bibliogr\u00e1ficas<\/h3>\n
    \n
  1. KANEKO, Yuki et al. Neuroendocrine carcinoma of the esophagus with an adenocarcinoma component. Clinical journal of gastroenterology, p. 1-5, 2019.<\/span><\/li>\n
  2. KIM, Kyeong-Ok et al. Clinical overview of extrapulmonary small cell carcinoma. Journal of Korean medical science, v. 21, n. 5, p. 833-837, 2006.<\/span><\/li>\n
  3. RINDI, Guido et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Modern Pathology, v. 31, n. 12, p. 1770, 2018.<\/span><\/li>\n
  4. SCHIZAS, Dimitrios et al. Neuroendocrine Tumors of the Esophagus: State of the Art in Diagnostic and Therapeutic Management. Journal of gastrointestinal cancer, v. 48, n. 4, p. 299-304, 2017.<\/span><\/li>\n
  5. WU, Zhu et al. Primary small cell carcinoma of esophagus: report of 9 cases and review of literature. World journal of gastroenterology: WJG, v. 10, n. 24, p. 3680, 2004.<\/span><\/li>\n<\/ol>\n

    Acesse o <\/span>Endoscopia Terap\u00eautica<\/span><\/a> para tomar contato com mais <\/span>artigos comentados<\/span><\/a>, <\/span>assuntos gerais<\/span><\/a>, <\/span>casos cl\u00ednicos<\/span><\/a>, <\/span>quizzes<\/span><\/a>, <\/span>classifica\u00e7\u00f5es<\/span><\/a> e mais!<\/span><\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

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