{"id":19957,"date":"2025-06-03T06:30:00","date_gmt":"2025-06-03T06:30:00","guid":{"rendered":"https:\/\/endoscopiaterapeutica.net\/pt\/?p=19957"},"modified":"2025-04-21T17:13:01","modified_gmt":"2025-04-21T17:13:01","slug":"doenca-de-whipple-o-que-o-endoscopista-precisa-saber","status":"publish","type":"post","link":"https:\/\/endoscopiaterapeutica.net\/pt\/assuntosgerais\/doenca-de-whipple-o-que-o-endoscopista-precisa-saber\/","title":{"rendered":"Doen\u00e7a de Whipple: O que o Endoscopista Precisa Saber"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/endoscopiaterapeutica.net\/pt\/?attachment_id=19958\"><img fetchpriority=\"high\" decoding=\"async\" width=\"498\" height=\"459\" src=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/doenca-de-Whipple.jpg\" alt=\"\" class=\"wp-image-19958\" srcset=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/doenca-de-Whipple.jpg?v=1744926138 498w, https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/doenca-de-Whipple-300x277.jpg?v=1744926138 300w\" sizes=\"(max-width: 498px) 100vw, 498px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><br>A doen\u00e7a de Whipple \u00e9 uma condi\u00e7\u00e3o infecciosa sist\u00eamica rara causada pela bact\u00e9ria <em>Tropheryma whipplei<\/em>, que acomete principalmente homens brancos, entre 40 e 60 anos. Como pode simular diversas patologias e afetar v\u00e1rios \u00f3rg\u00e3os, inclusive sem sintomas gastrointestinais, \u00e9 essencial que o endoscopista esteja atento a esse diagn\u00f3stico diferencial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Um pouco de hist\u00f3ria&#8230;<\/strong><\/h2>\n\n\n\n<p>Descrita pela primeira vez em 1907, a doen\u00e7a foi inicialmente chamada de &#8220;lipodistrofia intestinal&#8221; devido ao ac\u00famulo de gordura nos linf\u00e1ticos intestinais. A etiologia infecciosa foi confirmada em 1991 com a identifica\u00e7\u00e3o do <em>T. whipplei<\/em> via t\u00e9cnicas moleculares.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Epidemiologia:<\/strong><\/h2>\n\n\n\n<p>Apesar de ser rara (cerca de 30 casos\/ano), o <em>T. whipplei<\/em> \u00e9 est\u00e1 presente no ambiente, especialmente em esgoto e solo. \u00c9 mais comumente detectado em trabalhadores da \u00e1rea rural e de pouco saneamento. A doen\u00e7a cl\u00e1ssica \u00e9 rara mesmo entre os portadores assintom\u00e1ticos da bact\u00e9ria.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Manifesta\u00e7\u00f5es cl\u00ednicas<\/strong><\/h2>\n\n\n\n<p>A apresenta\u00e7\u00e3o cl\u00e1ssica envolve quatro sintomas principais:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Artralgias migrat\u00f3rias<\/strong> (geralmente anos antes dos sintomas digestivos)<\/li>\n\n\n\n<li><strong>Diarreia cr\u00f4nica<\/strong><\/li>\n\n\n\n<li><strong>Dor abdominal<\/strong><\/li>\n\n\n\n<li><strong>Perda de peso<\/strong><\/li>\n<\/ul>\n\n\n\n<p>Podem ocorrer manifesta\u00e7\u00f5es isoladas no sistema nervoso central ou em v\u00e1lvulas card\u00edacas. A doen\u00e7a tamb\u00e9m pode ser desmascarada por uso de imunossupressores, muitas vezes prescritos para doen\u00e7as reumatol\u00f3gicas presumidas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Papel do Endoscopista no Diagn\u00f3stico<\/strong><\/h2>\n\n\n\n<p>A endoscopia digestiva alta com <strong>bi\u00f3psias do intestino delgado (jejuno\/proximal do duodeno)<\/strong> \u00e9 essencial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Achados Endosc\u00f3picos Mais Comuns:<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Mucosa esbranqui\u00e7ada ou amarelada<\/strong>\n<ul class=\"wp-block-list\">\n<li>Aspecto de placas ou granula\u00e7\u00f5es finas na mucosa do duodeno ou jejuno.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Edema da mucosa<\/strong>\n<ul class=\"wp-block-list\">\n<li>A mucosa pode parecer espessada, p\u00e1lida ou opaca, com perda das pregas normais.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Linfangiectasia intestinal<\/strong>\n<ul class=\"wp-block-list\">\n<li>Dilata\u00e7\u00e3o dos vasos linf\u00e1ticos pode dar aspecto leitoso ou de mucosa brilhante e fri\u00e1vel.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>N\u00f3dulos milim\u00e9tricos<\/strong>\n<ul class=\"wp-block-list\">\n<li>Pequenos n\u00f3dulos na mucosa, principalmente no duodeno, conferem um aspecto de &#8220;mucosa em pedra de cal\u00e7amento&#8221;.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Aspecto de mucosa atr\u00f3fica ou ulcerada<\/strong>\n<ul class=\"wp-block-list\">\n<li>Em casos mais avan\u00e7ados, pode haver \u00e1reas de eros\u00e3o, atrofia ou at\u00e9 \u00falceras superficiais.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/endoscopiaterapeutica.net\/pt\/?attachment_id=19959\"><img decoding=\"async\" width=\"366\" height=\"338\" src=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-2.jpg\" alt=\"\" class=\"wp-image-19959\" srcset=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-2.jpg?v=1744927551 366w, https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-2-300x277.jpg?v=1744927551 300w\" sizes=\"(max-width: 366px) 100vw, 366px\" \/><\/a><figcaption class=\"wp-element-caption\">Achados endosc\u00f3picos em um paciente com Doen\u00e7a de Whipple: pontos esbranqui\u00e7ados com irregularidade de pregas duodenais e eros\u00f5es. Na cromoscopia com NBI e magnifica\u00e7\u00e3o se nota vilosidades engurgitadas com dilata\u00e7\u00e3o dos linf\u00e1ticos.<\/figcaption><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><strong>Investiga\u00e7\u00e3o<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Histologia com colora\u00e7\u00e3o PAS positiva em macr\u00f3fagos da l\u00e2mina pr\u00f3pria<\/li>\n\n\n\n<li>PCR para T. whipplei<\/li>\n\n\n\n<li>Imuno-histoqu\u00edmica<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/endoscopiaterapeutica.net\/pt\/?attachment_id=19960\"><img decoding=\"async\" width=\"442\" height=\"336\" src=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-macrofagos-intensamente-PAS-positivos.jpg\" alt=\"\" class=\"wp-image-19960\" srcset=\"https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-macrofagos-intensamente-PAS-positivos.jpg?v=1744928317 442w, https:\/\/endoscopiaterapeutica.net\/pt\/wp-content\/uploads\/2025\/04\/Doenca-de-Whipple-macrofagos-intensamente-PAS-positivos-300x228.jpg?v=1744928317 300w\" sizes=\"(max-width: 442px) 100vw, 442px\" \/><\/a><figcaption class=\"wp-element-caption\"><br>Doen\u00e7a de Whipple: macr\u00f3fagos intensamente PAS-positivos ocupando a l\u00e2mina pr\u00f3pria da mucosa. As c\u00e9lulas caliciformes tamb\u00e9m est\u00e3o positivamente coradas. A borda em escova dos enter\u00f3citos aparece marcada (como uma linha roxa intensa). Fonte: Bures et al. Gastroenterology Research and Practice 2013.<\/figcaption><\/figure>\n<\/div>\n\n\n<p>Se a suspeita for alta, mas a endoscopia n\u00e3o for diagn\u00f3stica, \u00e9 indicado investigar outros s\u00edtios acometidos (l\u00edquor, linfonodos, valvas, l\u00edquido sinovial).<\/p>\n\n\n\n<p>Importante: mesmo pacientes com apresenta\u00e7\u00e3o extraintestinal devem realizar endoscopia, j\u00e1 que a participa\u00e7\u00e3o intestinal subcl\u00ednica \u00e9 comum.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Tratamento<\/strong><\/h2>\n\n\n\n<p>A doen\u00e7a era fatal antes da era dos antibi\u00f3ticos. Hoje, o tratamento \u00e9 efetivo e dividido em duas fases:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Fase inicial (parenteral):<\/strong>\n<ul class=\"wp-block-list\">\n<li>Ceftriaxona 2g IV 1x\/dia ou<\/li>\n\n\n\n<li>Penicilina G 2-4 MU IV 4\/4h<\/li>\n\n\n\n<li>Dura\u00e7\u00e3o: 2 semanas (4 semanas se acometimento do SNC ou endocardite)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Fase de manuten\u00e7\u00e3o (oral por 1 ano):<\/strong>\n<ul class=\"wp-block-list\">\n<li>TMP-SMX (160\/800 mg) 2x\/dia<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<p><strong>Importante:<\/strong> O T. whipplei \u00e9 resistente a fluoroquinolonas e a atividade do TMP-SMX \u00e9 atribu\u00edda apenas ao sulfametoxazol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br><strong>Considera\u00e7\u00f5es finais para o endoscopista<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suspeite da doen\u00e7a em pacientes com s\u00edndrome diarreica cr\u00f4nica, perda de peso e artralgias, especialmente se do sexo masculino e com exposi\u00e7\u00e3o a solo ou esgoto.<\/li>\n\n\n\n<li>A bi\u00f3psia de intestino delgado \u00e9 a chave diagn\u00f3stica.<\/li>\n\n\n\n<li>O endoscopista pode ser o primeiro a levantar a hip\u00f3tese diagn\u00f3stica.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-pale-ocean-gradient-background has-background\">Mesmo rara, a doen\u00e7a de Whipple \u00e9 potencialmente fatal se n\u00e3o tratada, mas cur\u00e1vel com antibioticoterapia adequada. Estar atento \u00e0 possibilidade diagn\u00f3stica \u00e9 essencial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Refer\u00eancias<\/strong><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>G\u00fcnther U, Moos V, Offenm\u00fcller G, et al. Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. Medicine (Baltimore) 2015; 94:e714.<\/li>\n\n\n\n<li>Lagier JC, Fenollar F, Lepidi H, et al. Treatment of classic Whipple&#8217;s disease: from in vitro results to clinical outcome. J Antimicrob Chemother 2014; 69:219.<\/li>\n\n\n\n<li>Apstein MD, Schneider T. Whipple\u2019s disease. Uptodate. 2024.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Como citar este artigo<\/strong><\/h2>\n\n\n\n<p class=\"has-very-light-gray-to-cyan-bluish-gray-gradient-background has-background\">Orso IRB. Doen\u00e7a de Whipple: O que o Endoscopista Precisa Saber Endoscopia Terapeutica 2025 Vol I. Dispon\u00edvel em: <a href=\"https:\/\/endoscopiaterapeutica.net\/pt\/?p=19957\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/endoscopiaterapeutica.net\/pt\/assuntosgerais\/doenca-de-whipple-o-que-o-endoscopista-precisa-saber\/<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A doen\u00e7a de Whipple \u00e9 uma condi\u00e7\u00e3o infecciosa sist\u00eamica rara causada pela bact\u00e9ria Tropheryma&hellip;<\/p>\n","protected":false},"author":2464,"featured_media":19958,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[151],"tags":[292,800],"ano":[783],"tipo":[788],"volume":[263],"class_list":["post-19957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assuntosgerais","tag-endoscopia","tag-whipple","ano-783","tipo-assuntos-gerais","volume-volume-i"],"yoast_head":"<!-- This site is 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